The Bird-Flu Virus beginning to give up its Secrets!

Amid heightened concern over a possible epidemic of bird flu in humans, scientists in the United States and Taiwan are reporting critical new insights into the architecture of a key enzyme in the H5N1 avian influenza virus that enables the virus to spread. 

H5N1

Rommie E. Amaro and colleagues focused on what has been termed the “hot pocket,” or more technically “the 150-loop.” This chain of amino acids forms a cavity in the neuraminidase enzyme that facilitates H5N1’s spread. Anti-flu drugs called neuraminidase inhibitors work by entering and binding to the hot pocket, almost like a hand fitting into a glove.

In the new study, researchers report that the hot pocket actually can have internal shapes substantially different than previously believed. That new structural understanding of the 150-loop could be valuable in efforts to design new and more effective anti-flu drugs, they state. Drugs capable of fitting more snugly into the cavity could yield a class of neuraminidase inhibitors that are more effective against H5N1-like flu viruses.

The report is scheduled for the June 20 issue of the Journal of the American Chemical Society. The title of the article is “Remarkable Loop Flexibility in Avian Influenza N1 and Its Implications for Antiviral Drug Design.”

Here is a link to the original news item : http://www.sciencedaily.com/releases/2007/06/070618130937.htm

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4 Responses

  1. […] The Bird-Flu Virus beginning to give up its Secrets. Amid heightened concern over a possible epidemic of bird flu in humans, scientists in the United States and Taiwan are reporting critical new insights into the architecture of a key enzyme in the H5N1 avian influenza virus that enables the virus to spread. [ H5N1] Rommie E. The Bird-Flu Virus beginning to give up its Secrets! […]

  2. […] The Bird-Flu Virus beginning to give up its Secrets. Amid heightened concern over a possible epidemic of bird flu in humans, scientists in the United States and Taiwan are reporting critical new insights into the architecture of a key enzyme in the H5N1 avian influenza virus that enables the virus to spread. [ H5N1] Rommie E. The Bird-Flu Virus beginning to give up its Secrets! […]

  3. […] The Bird-Flu Virus beginning to give up its Secrets. Amid heightened concern over a possible epidemic of bird flu in humans, scientists in the United States and Taiwan are reporting critical new insights into the architecture of a key enzyme in the H5N1 avian influenza virus that enables the virus to spread. [ H5N1] Rommie E. The Bird-Flu Virus beginning to give up its Secrets! […]

  4. Dear Health Minister Dr Chua Soi Lek,
    I would like to propose by importing initial 1000 unit blood pressure into malaysia to educate the local about monitor individual blood presuure who are above 45 year of age.
    As high blood pressure can cause heart and kidney failure and thus lead to diabitie.
    I therefore would like to ask for permission from your Ministry of malaysia to operate this programme in various comunities centre .
    I can be contacted : Steinbuehlallee 210 , Allschwil Ch-4123
    SWITZERLAND, tEL 0041765127481
    Kind regards
    Chee raymond

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